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10748056 Methods and systems for predicting DNA accessibility in the pan-cancer genome  
Techniques are provided for predicting DNA accessibility. DNase-seq data files and RNA-seq data files for a plurality of cell types are paired by assigning DNase-seq data files to RNA-seq data...
10748040 System and method for automatic assessment of cancer  
Glioblastoma multiforme (GBM) is the most aggressive type of brain cancer. It is critical to determine the most effective patient-specific treatment quickly. Exemplary embodiments use a...
10746726 Method for assessing therapeutic effect of anti-cancer agent having anti-CD4 antibody as active ingredient  
Means that enables monitoring of an anticancer effect of an anti-CD4 antibody or an anticancer drug targeting an immune checkpoint is disclosed. The method for testing a therapeutic effect of a...
10746651 Optical method for predicting treatment response, survival and recurrence of esophageal cancer patients  
The present invention provides an optical method for predicting treatment response, survival and recurrence of esophageal cancer patients, comprising analyzing the spectral signatures of patient's...
10745761 Method and systems for lung cancer diagnosis  
The present invention relates to methods and systems for high risk screening, diagnosis, prognosis, and surveillance of lung cancer. Accordingly, in one aspect, the invention provides a method for...
10745760 Biopsy-driven genomic signature for prostate cancer prognosis  
There is provided herein, systems, devices and methods for determining a risk of recurrence of cancer following a cancer therapy of a patient by determining genomic instability of a tumour. There...
10745703 Compositions and methods for treating cancer  
A method of one or more of, inhibiting motility, migration, dispersal, and metastasis of a cell that expresses an RPTP, which is proteolytically cleaved to form intracellular fragments in the cell...
10745489 Targeting o-acetylated gd2 ganglioside as a new therapeutic and diagnostic strategy for Cancer Stem Cells cancer  
An antibody recognizing the O-acetylated-GD2 ganglioside for the treatment of Cancer Stem Cells (CSC) cancer, a pharmaceutical composition including the antibody for treating a CSC cancer and a...
10745487 Method of treating cancer by administering an anti-LGR5 monoclonal antibody  
The present invention relates generally to the field of cancer biology. Some embodiments of the methods and compositions provided herein relate to administration of humanized antibodies or...
10745478 Antibody fusion protein and related compositions for targeting cancer  
Disclosed herein are compositions comprising a polypeptide with at least two domains, wherein the first domain is capable of binding CD3 and the second domain is capable of binding to a cancer...
10745433 Compounds for inhibiting cancer and virus  
The invention relates to compounds for inhibiting a cancer cell or a virus. Particularly, the invention provides compounds for inhibiting, treating and/or preventing cancer and Zika virus.
10745429 Phospholidines that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer  
This disclosure provides compounds with Bcl inhibitory activity based on a new chemical scaffold, as shown in Formula (I). The phospholidine compounds can include a P-phenyl phospholidine moiety...
10745380 Pyridine derivatives and their use in the treatment of cancer and hemoglobinopathies  
A compound of formula (Ia), (Ib) or (Ic) wherein: n is 1 or 2; RN is H or Me; R1 is optionally one or more halo or methyl groups; R2a and R2b are independently selected from the group consisting...
10745355 Anti-cancer compounds  
The present invention relates to new pharmaceutical agents, and to their use in the treatment of proliferative diseases, such as cancer (in particular, brain cancer).
10744186 Method of treating cancer with compositions comprising IL-31  
A method for treating cancer and/or preventing or reducing metastasis or treating angiogenesis related disorders comprising the step of administering IL-31 or peptide which is at least about 70%,...
10744172 Tropism modified cancer terminator virus (Ad.5/3 CTV;Ad.5/3-CTV-M7)  
A tropism modified cancer terminator virus (Ad.5/3-CTV; Ad.5/3-CTV-M7) has been found to have infectivity that is Coxsackie Adenoviral Receptor (CAR) independent. The Ad.5/3-CTV (Ad.5/3-CTV-M7)...
10744171 Sequential anti-cancer treatment  
Human clinical use of a chimeric poliovirus construct has demonstrated excellent anti-tumor effect. Sequential treatment with the virus construct followed by chemotherapy drugs increases the...
10744148 Methods of treating breast cancer that overexpress AKT kinase  
This application relates to combination therapies including triciribine compounds and epidermal growth factor receptor inhibitor compounds, particularly erlotinib-like compounds and compositions...
10744141 Compositions and methods for treating cancer  
A method of treating cancer in a subject in need thereof includes administering to the subject therapeutically effective amounts of a PP2A activator and a protein kinase inhibitor.
10744134 Pharmaceutical composition for cancer immunotherapy and/or immunological activation containing diamino heterocyclic carboxamide compound as active ingredient  
6-ethyl-3-({3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin -1-yl]phenyl}amino)-5-(tetrahydro-2H-pyran-4-ylamino)pyrazin e-2-carboxamide or a pharmaceutically acceptable salt thereof has an...
10744133 Compound for anti-cancer therapy that acts by targeting GOF mutant p53 and stimulates p73 to restore the p53 pathway signaling  
The invention includes compositions comprising NSC59984 or a derivative or analogue thereof and a pharmaceutically acceptable carrier. The invention further includes methods of treating or...
10744130 Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan  
Provided are methods for treating pancreatic cancer in a patient by administering liposomal irinotecan (MM-398) alone or in combination with additional therapeutic agents. In one embodiment, the...
10744129 Therapy of small-cell lung cancer (SCLC) with a topoisomerase-I inhibiting antibody-drug conjugate (ADC) targeting Trop-2  
The present invention relates to treatment of SCLC with therapeutic ADCs comprising a drug attached to an anti-Trop-2 antibody or antigen-binding antibody fragment. Preferably, the drug is SN-38....
10744123 Methods and dosing regimens using ibudilast and a second agent for cancer therapy  
Methods and dosing regimens for treating glioblastoma or recurrent glioblastoma and its associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine) or a...
10744110 Methods of treating lung cancer  
The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an...
10741270 Size-based analysis of cell-free tumor DNA for classifying level of cancer  
A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least...
10739346 Diagnosis of cancer by detecting auto-antibodies against EGF-receptor  
The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against epidermal growth factor receptor (EGFR) in a sample...
10738363 Analyzer and analytical method for predicting prognosis of cancer radiotherapy  
The present invention provides an analyzer for predicting a prognosis of cancer radiotherapy, including a detection device and an arithmetic device. In a specimen, expression levels of a plurality...
10738362 Determining prostate cancer recurrence using polymorphisms in angiogenesis-related genes  
In particular, disclosed is a method for treating a patient with prostate cancer that involves genotyping a nucleic acid sample from the subject for one or more single nucleotide polymorphism...
10738355 Individualized vaccines for cancer  
The present invention relates to the provision of vaccines which are specific for a patient's tumor and are potentially useful for immunotherapy of the primary tumor as well as tumor metastases....
10738310 Treating cancer deficient in FANCA, FANCD2, FANCE, or FANCG with an ATM inhibitor  
This present invention compositions and methods of treating cancer and methods of accessing/monitoring the responsiveness of a cancer cell to a therapeutic compound.
10738279 Modified NK-92 cells for treating cancer  
Provided herein are NK-92 cells expressing at least one CAR and at least one Fc receptor. Also provided are methods of treatment of a patient having or suspected of having a disease that is...
10738129 Anti-survivin antibodies for cancer therapy  
Provided are survivin specific antibodies, nucleic acids encoding the antibodies and methods for treating tumors comprising survivin-expressing cells by administration of the antibodies. The...
10738108 Monoclonal antibodies against claudin-18 for treatment of cancer  
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing CLD18, including tumor-related diseases such as gastric...
10738100 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10738094 Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers  
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The...
10738042 Phosphonamidates that are Bcl family antagonists for use in clinical management of conditions caused or mediated by senescent cells and for treating cancer  
This disclosure provides compounds with Bcl inhibitory activity based on a new chemical scaffold, as shown in Formula (I): Phosphonamidate compounds disclosed herein typically include a P-phenyl...
10738016 BRD4-kinase inhibitors as cancer therapeutics  
Disclosed herein are compounds that are inhibitors of BDR4 and their use in the treatment of cancer. Methods of screening for selective inhibitors of BDR4 are also disclosed. In certain aspects,...
10737995 Nuclear receptor modulators and their use for the treatment and prevention of cancer  
Disclosed are compounds which are nuclear receptor modulators that can act as antagonists to the androgen receptor, for example, a compound of Formula I: wherein R1 to R5 and X1 to X5 are as...
10736974 Scaffolds and multifunctional intermediates for imaging PSMA and cancer therapy  
Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express...
10736972 Methods of treatment using ultrasmall nanoparticles to induce cell death of nutrient-deprived cancer cells via ferroptosis  
Described herein is a method of induced cell death via ferroptosis by nanoparticle ingestion. Moreover, the present disclosure describes the administration of high concentrations of ultrasmall...
10736964 Immunomagnetic nanocapsule and kit for treating cancer  
An immunomagnetic nanocapsule includes a core, a shell and an outer layer. The shell is formed by a complex, and the complex is fabricated by a combination of fucoidan, oxidized dextran, and a...
10736949 Radiohalogenated agents for in situ immune modulated cancer vaccination  
A method of treating a malignant solid tumor in a subject is disclosed herein. The method includes the steps of administering to the subject an immunomodulatory dose of a radiohalogenated compound...
10736947 Neospora for use in treating cancer and infectious diseases  
The present invention relates to a strain of Neospora caninum for use in treating cancer or infectious diseases.
10736940 Combined preparations for the treatment of cancer  
Combined preparations for the treatment of cancer are described. The combined preparations comprise: (a) LAG-3 protein, or a derivative thereof that is able to bind to MHC class II molecules; and...
10736921 Genetically modified NK-92 cells and monoclonal antibodies for the treatment of cancer  
This invention is directed to treatment of a subject having or suspected of having a cancer comprising administering to the subject a monoclonal antibody and NK-92 expressing Fc receptor.
10736913 Use of inosine for cancer immunotherapy  
Disclosed are formulations for the treatment of cancer including inosine or a related compound in combination with an immune checkpoint inhibitor including but not limited to immune checkpoint...
10736902 Method of treating triple negative breast cancer  
A method of treating a patient suffering from TNBC by a multidisciplinary method involving treating the patient with a plurality of the following treatments: i) one or more checkpoint inhibitors;...
10736897 Compounds and methods of use thereof for treatment of cancer  
Compounds having activity as inhibitors of G12C mutant KRAS protein are provided. The compounds have the following structure (I): or a pharmaceutically acceptable salt, stereoisomer, isotopic form...
10736887 Quinoline derivative for treating gastric cancer  
Provided in the present invention is a quinoline derivative for treating gastric cancer. 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinoli n-7-yl]oxy]methyl]cyclopropylamine or a...

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